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However, since these rats are known to grow tumors at a high and very variable rate, the study was considered flawed in design and its findings unsubstantiated.

The biobreeding rat a. Like NOD mice , biobreeding rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features of human type 1 diabetes and has contributed greatly to the research of T1DM pathogenesis.

The Brattleboro rat is a strain that was developed by Henry A. It has a naturally occurring genetic mutation that makes specimens unable to produce the hormone vasopressin , which helps control kidney function.

The rats were being raised for laboratory use by Dr. Henry Schroeder and technician Tim Vinton, who noticed that the litter of 17 drank and urinated excessively.

Hairless laboratory rats provide researchers with valuable data regarding compromised immune systems and genetic kidney diseases. It is estimated that there are over 25 genes that cause recessive hairlessness in laboratory rats.

The Lewis rat was developed by Margaret Lewis from Wistar stock in the early s. Characteristics include albino coloring, docile behavior, and low fertility.

Second, Lewis rats are prone to develop a spontaneous transplantable lymphatic leukaemia. Lastly, when in advanced age, they sometimes develop spontaneous glomerular sclerosis.

Current research applications include transplantation research, induced arthritis and inflammation, experimental allergic encephalitis, and STZ-induced diabetes.

Although the genetic defect was not known for many years, it was identified in the year as a mutation in the gene MERTK.

This mutation results in defective retinal pigment epithelium phagocytosis of photoreceptor outer segments. Its phenotype is similar to the widely researched reeler mouse.

Shaking rat Kawasaki was first described in The Zucker rat was bred to be a genetic model for research on obesity and hypertension. They are named after Lois M.

Zucker and Theodore F. Zucker, pioneer researchers in the study of the genetics of obesity. Obese Zucker rats have high levels of lipids and cholesterol in their bloodstream, are resistant to insulin without being hyperglycemic , and gain weight from an increase in both the size and number of fat cells.

A knockout rat also spelled knock out or knock-out is a genetically engineered rat with a single gene turned off through a targeted mutation.

Knockout rats can mimic human diseases, and are important tools for studying gene function and for drug discovery and development.

Knockout rat disease models for Parkinson's disease , Alzheimer's disease , hypertension , and diabetes , using zinc-finger nuclease technology, are being commercialized by SAGE Labs.

From Wikipedia, the free encyclopedia. Inbred strains of Rattus norvegicus used for scientific research. For other uses, see Lab rat disambiguation.

The albino laboratory rat with its red eyes and white fur is an iconic model organism for scientific research in a variety of fields.

Play media. Main article: Biobreeding rat. Main article: Brattleboro rat. See also: Hairless fancy rat. Main article: Knockout rat. ILAR Journal.

Academic Press. Bio Resource Newsletter. National Institute of Genetics. Retrieved 20 December Watson "Psychical development of the white rat", Ph.

Biographical Memoirs of the National Academy of Sciences. The oestrous cycle in the rat and its associated phenomena. University of California Press.

The Laboratory Rat. PHoto Courtesy of Laurel L. The Fawn, Champagne, or Beige hooded rat is more commonly called an orange hooded or red hooded by those who are not quite familiar with the rat colors.

There are also other shades, but these will be the three we mention here. These coats can range from a lighter beige that seems like a light orange, to a very fiery, deep color that reminds one of a redheaded human.

Meet Mouse, the Agouti Hooded Rat! Photo courtesy of Laurel L. The agouti color is a reddish cinnamon brown; it is multifaceted because the individual hairs are banded!

They are banded with varying shades of brown, red, cinnamon, black, and even gray. Is My Rat Dying? The Hooded Rat We have all seen hooded rats, especially in dreadful stores such as Petsmart.

Black and White Hooded Rat The black and white hooded rat is the most common hooded color that you will see.

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The cat is much larger than the rat. North West London slang term for Vagina, as in get your rat out.

A wad of shed hair used as part of a hairstyle. To kill rats. A medium-sized rodent belonging to the genus Rattus.

A term indiscriminately applied to numerous members of several rodent families e. A person who is known for betrayal; a scoundrel; a quisling.

An informant or snitch. A person who routinely spends time at a particular location. A scratch or a score.

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